Details
Normomed Indications
˗ Viral infections caused by herpes simplex virus types 1 and 2, chickenpox virus, cytomegalovirus, Epstein-Barr virus, measles virus, mumps virus, including in patients with immunodeficiency;
˗ viral respiratory infections;
˗ papillomavirus infections of the skin and mucous membranes: acute condyloma, papillomavirus infection of the vulva, vagina and cervix (as part of complex therapy);
˗ acute viral encephalitis (as part of complex therapy);
˗ viral hepatitis (as part of complex therapy);
˗ subacute sclerosing panencephalitis (as part of complex therapy).
Contraindications
˗ Hypersensitivity to any component of the drug;
˗ gout;
˗ hyperuricemia;
˗ urolithiasis;
˗ chronic renal failure;
˗ arrhythmias;
˗ pregnancy and breastfeeding;
˗ children under 3 years old.
Dosage & Administration
The drug is administered orally. Used after eating, drinking a small amount of water.
The daily dose depends on body weight, course and severity of the disease, the patient's condition.
Adults and children over 12 years of age: 50 mg / kg body weight (usually 6-8 tablets, divided into 3-4 doses), the maximum daily dose is 4 g.
Children aged 3 to 12 years - 50 mg / kg body weight (usually 1 tablet per 10 kg body weight for a child weighing 10-20 kg, with a body weight greater than 20 kg prescribe a dose for adults) for 3-4 receptions per day, the maximum daily dose - 4 g. To facilitate swallowing, the tablet can be crushed.
Duration of treatment.
Acute diseases: in short-term diseases the course of treatment is from 5 to 14 days. After reducing the severity of symptoms, treatment should be continued for another 1-2 days or longer, depending on the course of the disease, the patient's condition.
Long-term viral diseases: treatment should be continued for 1-2 weeks after the onset of symptoms or longer, depending on the course of the disease, the patient's condition.
Recurrent diseases: at the initial stage of treatment, the same recommendations are used as for acute diseases. During maintenance therapy, the dose can be reduced to 500-1000 mg (1-2 tablets) per day. At the first signs of recurrence, it is necessary to resume taking the daily dose recommended for acute diseases, and continue taking it for 1-2 days after the disappearance of symptoms. The course of treatment can be repeated several times if necessary and depending on the patient's condition (as recommended by the doctor).
Chronic diseases: the drug is prescribed in a daily dose of 50 mg / kg body weight according to the following schemes:
asymptomatic diseases - take for 30 days with a break of 60 days; diseases with moderate symptoms - take for 60 days with a break of 30 days;
diseases with severe symptoms - apply for 90 days with a break of 30 days.
The course of treatment should be repeated as many times as necessary, and it is necessary to constantly monitor the patient's condition and indications for prolongation of therapy.
For infections caused by human papilloma virus (external genital warts (genital warts) or papillomavirus infection of the cervical canal) take 3 g (2 tablets 3 times a day) for 14-28 days as monotherapy or as an adjunct to topical therapy or surgery according to the following schemes:
a) for the treatment of patients from the "low risk" group (patients with normal immunity or patients with a low risk of recurrence) the drug is used for 14-28 days until the maximum eradication of the virus, then a break of 2 months should be taken. The course of treatment can be repeated at the same dose, with constant monitoring of the patient's condition and indications for prolongation of therapy;
b) for the treatment of patients from the group of "high risk" * (patients with immunodeficiency or high risk of recurrence) the drug is used 5 days a week, successively 1-2 weeks a month for 3 months. The course of treatment should be repeated as many times as necessary, and it is necessary to constantly monitor the patient's condition and indications for prolongation of therapy.
* "High risk" factors in patients with recurrence or dysplasia of the cervix, or papillomavirus infection of the genitals, as in other similar diseases, include:
immunodeficiency caused
- the presence of a history of chronic or recurrent infections or sexually transmitted diseases;
- chemotherapy;
- chronic alcoholism;
long-term use of oral contraceptives (2 years and longer);
the level of folate in erythrocytes is less than 660 nmol / l;
several sexual partners or a change of permanent sexual partner;
frequent vaginal intercourse (≥ 2-6 times a week) or anal sex;
atopy (hereditary predisposition to hypersensitivity);
poorly controlled diabetes;
smoking;
papillomavirus infection of the genitals, which lasts more than 2 years or has 3 or more recurrences in the anamnesis;
negative history of skin warts in childhood.
In subacute sclerosing panencephalitis, the daily dose is 100 mg / kg body weight, the maximum dose is 3-4 g / day, and it is necessary to constantly monitor the patient's condition and indications for prolongation of therapy.
