Depo Provera injection suspension 3,3ml 500mg Medroxyprogesterone acetate Депо-Провера

Depo Provera Indications

In oncology:
- with recurrent and / or metastatic breast cancer;
- with recurrent and / or metastatic endometrial cancer;
- with recurrent and / or metastatic renal cell carcinoma;
- metastases of prostate cancer.

In gynecology:
- for the treatment of endometriosis;
- for the treatment of vasomotor menopausal manifestations;
- with the purpose of contraception.

Dosage & Administration

Oncology
Mammary cancer
The recommended regimen for administration of Depo-Provera - 500-1000 mg / day / m for 28 days and then switch to a maintenance dose - 500 mg 2 times a week for as long as the treatment remains effective.
Endometrial cancer and kidney
The recommended initial dose - 400-1000 mg / m 1 times a week. If for several weeks or months began to improve the state of the process and achieved stabilization, you can move on to maintenance therapy at a dose of 400 mg 1 time per month.
Metastatic prostate cancer
The initial dose of 500 mg / m 2 once a week for 3 months and then maintenance therapy - 500 mg 1 time per week.
Gynecology
The use of combined estrogen / progestin therapy in postmenopausal women must be limited in view of the short period and the risk of indications in each case, and should be monitored periodically.
Endometriosis
V / m 1 50 mg weekly or 100 mg every 1 to 2 weeks for 6 months.
Vasomotor symptoms during menopause
V / m 1 150 mg every 12 weeks.
Contraception
Before the introduction of the vial should be vigorously shaken until a homogeneous suspension. The recommended dose is 150 mg / m (in the gluteal or deltoid muscle) every three months.

Contradictions

During pregnancy, vaginal bleeding of unknown etiology, severe liver dysfunction, hypersensitivity to medroxyprogesterone acetate or any other components of the preparation. Appointment of the drug as a contraceptive is contraindicated in cases of diagnosed or suspected breast malignancy. The drug Depo-Provera is not indicated for use before the onset of the menstrual cycle.