Details
Glibenclamide Indications
Insulin diabetes of adults (diabetes type II) if other measures, such as strict diet, reducing excess body weight, sufficient physical activity did not lead to a satisfactory correction of blood glucose.
Contraindications
Hypersensitivity to glibenclamide or auxiliary substances, sulfonylureas, to sulfonamides, diuretics, sulfonamide derivatives and to probenecid. In cases if treatment with insulin is required: diabetes mellitus, full secondary treatment failure glibenclamide in diabetes mellitus type II, metabolism with a bias toward acidosis, prekomy or diabetic coma. Condition resection of the pancreas. Severe hepatic impairment. Severe renal impairment.
Dosage & Administration
The drug should be used only as directed by a doctor and always corrected diet. Dosage depends on the results of investigation of metabolism (blood sugar and urine).
First and subsequent appointments. Therapy start, if possible, with the lowest possible doses, primarily concerned patients with increased susceptibility to hypoglycemia and weighing less than 50 kg.
The first destination is from ½ to 1 tablet (corresponding to 2.5-5 mg glibenclamide) per day. With inadequate correction of metabolic gradually increase the dose at intervals of several days to one week, to the required daily therapeutic dose is 3 tablets (corresponding to 15 mg of glibenclamide) per day.
