Details
Sporaxol Indication
Mycoses caused by pathogens susceptible to itraconazole, vulvovaginal candidiasis;
Dermatological / ophthalmic fungal disease - dermatomycosis, pityriasis versicolor, fungal keratitis;
Oral candidiasis;
Onychomycosis caused by dermatophytes and / or yeasts;
Systemic mycoses - systemic candidiasis or aspergillosis, cryptococcosis, including cryptococcal meningitis (Immunocompromised patients with cryptococcosis and in all patients with cryptococcosis of the central nervous system.
Sporaxol is prescribed only in case of failure treatment with other antifungal medicines); histoplasmosis, sporotrichosis, parakoktsydioyidoz, blastomycosis and other systemic fungal infections, which are extremely rare.
Contraindications
Hypersensitivity to the drug or its components. Concomitant use of drugs (see. Section "Interaction with other medicinal products and other forms of interaction"):
- Substrates of CYP3A4, which can prolong the interval QT, such as astemizole, bepridil, cisapride, dofetilide, levatsetylmetadol (levometadyl) mizolastyn, pimozide, quinidine, sertindole and terfenadine. Concomitant use can increase the concentration of drugs in blood plasma that may lead to QT prolongation and rare cases to flutter, ventricular fibrillation;
- Inhibitors of HMG-CoA-reductase inhibitors that are metabolized by CYP3A4, such as atorvastatin, lovastatin and simvastatin;
- Oral midazolam and triazolam;
- Ergot alkaloids, such as dihydroergotamine, ergometrine (ergonovine), ergotamine and metylerhometryn (metylerhonovin);
- Eletryptan;
- Nizoldypin.
Dosage & administration
Used internally. For optimal absorption of the drug should be used Sporaksol capsule immediately after eating. The capsules should be swallowed whole.