Siofor 60 tablets 500mg / 850mg Metformin Anti Diabetes Сиофор

Siofor Indications

The treatment of diabetes type II in adults and children over 10 years, especially in the presence of excess body weight after failure of diet and physical activity.

Children aged over 10 years Siofor 500 can be used as monotherapy or in combination with insulin.

Contraindications

Hypersensitivity to the active substance or to any excipient.

Diabetic ketoacidosis, diabetic prekomy.

Renal insufficiency moderate (stage IIIb) and or severe renal impairment (creatine clearance well <45 mL / min or GFR <45 ml / min. / 1.73 m2).

Acute conditions liable to affect renal function, such as dehydration, severe infection, shock.

Acute or chronic disease may cause tissue hypoxia, such as decompensated heart failure, respiratory failure, recent myocardial infarction, shock.

Hepatic insufficiency, acute alcohol intoxication, alcoholism.

Dosage & Administration

Adults

Monotherapy and combination with other oral antidiabetic agents.

The initial dose is 1 tablet covered with film membrane, 2-3 times a day, which should be taken during or after meals. After 10-15 days the dose should be adjusted depending on the performance level of blood sugar. Gradual dose escalation positive effect on the digestive tract tolerability. The maximum daily dose of metformin hydrochloride is 3 g, divided into 3 doses. If transfer from another oral antidiabetic agent metformin hydrochloride should be to abolish the previous tool, and then start therapy in the above mentioned doses.

Children under 10 years

Monotherapy or combination therapy together with insulin.

Siofor drug can be used in children under 10 years.

The usual starting dose is 500 mg or 850 mg metformin hydrochloride 1 per day during or after meals. After 10-15 days the dose should be adjusted based on blood glucose. Gradual dose escalation improves tolerability of the digestive tract. The maximum daily dose of metformin hydrochloride is 2 g per day, divided into 2-3 receptions.

Elderly patients

Because of possible renal dysfunction in elderly patients the dose determined based on kidney samples. Requires regular monitoring of renal function.