Noliprel arginin forte 30 tabl Perindopril arginine COMB DRUG Нолипрел

Noliprel Indications

- Essential hypertension.

- Noliprel arginine Forte is appointed as additional blood pressure control medicament, when used as monotherapy perindopril if necessary.

Dosage & Administration

For oral administration
Adults. One tablet per day, preferably in the morning before meals. It may be recommended to individual selection of doses of the components. In the case of the clinical feasibility of possible appointment of a transition from monotherapy to treat drug immediately Noliprel arginine Forte.
Elderly patients. Treatment should begin considering indicators of blood pressure and renal function.
Patients with hepatic impairment. Patients with severely impaired hepatic function are contraindicated drug treatment. In patients with moderately impaired hepatic function it is not necessary to dose adjustment.
Patients with impaired renal function. In severe renal insufficiency (creatinine clearance <30 mL / min), treatment with the drug is contraindicated.

Patients with creatinine clearance ≥30 and <60 ml / min are recommended to start treatment with adequate doses of active drug substances (perindopril and indapamide) in any combination.

Patients with creatinine clearance> 60 mL / min dose adjustment is required. Average medical monitoring should include frequent monitoring of creatinine and potassium levels in the blood.

Contradictions

Conditional perindopril: Hypersensitivity to perindopril or other ACE inhibitors; angioneurotic edema (angioedema) after the application of any ACE inhibitors in history; congenital or idiopathic angioedema.

Conditional indapamide: hypersensitivity to indapamide or other sulfonylurea drugs; severe renal insufficiency (creatinine clearance <30 mL / min); severe hepatic impairment; hepatic encephalopathy; hypokalemia; as a general rule, the drug is not recommended for use in combination with drugs that are not related to the antiarrhythmic agents that can cause the development of paroxysmal ventricular tachycardia of the type "pirouette.

Conditional drug Noliprel arginine / arginine Noliprel Forte: Hypersensitivity to any excipients. Due to lack of sufficient clinical experience Noliprel arginine / arginine Noliprel Forte should not be administered to patients who are on hemodialysis, as well as in patients with untreated heart failure decompensation phase.