Details
PK Merz Indications
Intensive care and initial treatment of akinetic crisis with a sharp aggravation of the symptoms of Parkinson's disease.
Increased ability to focus attention (vigilance) in after comatose states of various etiologies in a hospital setting.
Contradictions
- hypersensitivity to amantadine or any other components of the drug;
- decompensated heart failure (NYHA IV stage);
- cardiomyopathy, and myocarditis;
- antrioventikulyarnaya block II and III level;
-bradycardia (less than 55 beats / min.);
- prolonged interval of Q-T (Bazett Q-Tc> 420 ms) or with marked U-waves, or with congenital Q-T-syndrome in the family history;
- severe ventricular arrhythmias, including chaotic polymorphic ventricular tachycardia;
-budipine simultaneous treatment or other drugs prolonging the interval Q-T (See Interactions.);
- reduced level of potassium or magnesium in the blood;
- severe renal insufficiency (creatinine clearance <10 mL / min);
- childhood;
- lactation.
Dosage & Administration
Treatment of patients with Parkinson's syndrome.
With a sharp aggravation of the symptoms of Parkinson's disease with akinetic crisis in / in the dose of 200 mg amantadine sulphate is administered 1-3 times a day. The rate of administration should not exceed 55 drops per minute, equivalent to an infusion time of about 3 hours.
Vigilance.
To improve the state of vigilance in various etiologies postkomatoznom therapy in a daily dose of 200 mg amantadine sulphate, which is administered as a slow infusion (> 3 hours) may be conducted in the initial period of 3-5 days. Depending on the clinical treatment can then be continued, if possible, in oral form, - up to 4 weeks at a dose of 200 mg per day amantadine sulfate.
