Details
Doxepin Indications
Neurotic disorders with symptoms of depression or anxiety. Organic neuroses associated with insomnia. Depressive and anxiety disorders in alcoholism. Depression and anxiety associated with somatic disorders and diseases.
Depression, accompanied by fear and anxiety on the background of psychosis, including involutional depression and the depressive phase of bipolar disorder.
Contradictions
Hypersensitivity to the drug, cross-sensitivity. Mania; severe liver function; glaucoma; urinary retention; concurrent use with MAO inhibitors.
Dosage & Administration
taken orally. Assign adults and children over the age of 12 years.
Dose picked individually depending on the severity of symptoms and therapeutic effect.
Doxepin dose is 30-300 mg / day. The dose up to 100 mg may be used singly or divided. Dosages above 100 mg, 3 to be used in reception. The maximum single dose - 100 mg (applied before bedtime).
For moderate or severe symptoms, the usual initial dose is 75 mg / day.
In most patients, this dose is effective. In severe forms of the disease is increased to a dose of 300 mg (3 doses) per day. After achieving a positive therapeutic effect of correcting the dose to the minimum maintenance.
Anxiolytic (anti-anxiety) effects doxepin is achieved before the antidepressant. The antidepressant effect appears after 2-3 weeks of treatment.
Elderly patients with mild symptoms of the disease is recommended half dose doxepin.
The positive clinical effect was obtained after the application of doxepin hydrochloride at a dose of 30 mg / day.
Patients with impaired hepatic function should be to reduce the dose of the drug.
