Depakin Enteric 100 tablets 300mg Valproate semisodium Депакин Хроно Epileptic seizures

Depakin Enteric Indications

For adults, as monotherapy or in combination with other antiepileptic drugs:
- For the treatment of generalized seizures (clonic, tonic, tonic-clonic seizures, absences, myoclonic and atonic seizures); Gastaut Syndrome Lennox-;

- For the treatment of partial seizures (partial seizures with secondary generalization or not).

For children, as monotherapy or in combination with other antiepileptic drugs:
- For the treatment of generalized seizures (clonic, tonic, tonic-clonic seizures, absences, myoclonic and atonic seizures); Gastaut Syndrome Lennox-;

- For the treatment of partial seizures (partial seizures with secondary generalization or not).
Treatment of mania in bipolar disorder syndrome.
 

Contraindications

Hypersensitivity to valproate, dyvalproatu, valpromidu or to any component of the drug in history.
Acute hepatitis.
Chronic hepatitis.
Cases of severe hepatitis in an individual or a family history of the patient, especially caused by drugs.
Hepatic porphyria.
The combination of mefloquine and St. John's wort extract. 
Children weighing less than 17 kg.

Children under 6 years (in connection with the risks of the pill in the airway during swallowing).

Dosage & Administration

The recommended average daily dose of sodium valproate is 20-30 mg / kg for children and adults. Daily doses above 35 mg / kg for children and 30 mg / kg for adults is rarely necessary monotherapy agent.

The therapeutic effect usually occurs when the drug concentration in plasma reaches 40-100 mg / L (278-694 mmol / l).

The dose should be reduced if the concentration of drug in plasma are above 200 mg / L (1388 mg / l). The level of drug in plasma is also recommended to determine the application dose of 50 mg / kg per day or higher.

Blood samples to determine the concentration of valproic acid preferably take the morning before receiving the first dose.