Medrol (Methylprednisolone) 4mg 30 tablets Медрол

Medrol Indications

Endocrine diseases.

Primary and secondary insufficiency of the adrenal cortex (first-line drugs are hydrocortisone or cortisone; if necessary, synthetic analogues can be used in combination with mineralocorticoids; simultaneous use of mineralocorticoids is especially important for the treatment of young children).

Congenital hyperplasia of the adrenal glands.

Non-purulent thyroiditis.

Hypercalcemia in malignant tumors.

Non-endocrine diseases.

1. Rheumatic diseases.

As an additional therapy for short-term use (to remove the patient from an acute condition or exacerbation of the process) in the following diseases:

· Psoriatic arthritis;

· Rheumatoid arthritis, including juvenile rheumatoid arthritis (in some cases, low-dose maintenance therapy may be required);

· Ankylosing spondylitis;

· Acute and subacute bursitis;

· Acute nonspecific tendosynovitis;

· Acute gouty arthritis;

· Post-traumatic osteoarthritis;

· Synovitis in osteoarthritis;

· Epicondylitis.

2. Collagenosis.

In the period of exacerbation or in some cases as maintenance therapy for the following diseases:

· Systemic lupus erythematosus;

· Systemic dermatomyositis (polymyositis);

· Acute rheumatic heart disease;

· Rheumatic polymyalgia in giant cell arteritis.

3. Skin diseases.

· Bubbles;

· Bullous herpetiform dermatitis;

· Severe erythema multiforme (Stevens-Johnson syndrome);

· Exfoliative dermatitis;

· Fungoid mycosis;

· Severe psoriasis;

· Severe seborrheic dermatitis.

4. Allergic conditions.

For the treatment of the following severe and disabling allergic conditions in case of ineffectiveness of standard treatment:

· Seasonal or perennial allergic rhinitis;

· Serum sickness;

· Bronchial asthma;

· Hypersensitivity reactions to drugs;

· Contact dermatitis;

· Atopic dermatitis.

5. Eye diseases.

Severe acute and chronic allergic and inflammatory processes with damage to the eyes and appendages, such as:

· Allergic marginal corneal ulcers;

· Eye damage caused by Herpes zoster;

· Inflammation of the front of the eye;

· Diffuse posterior uveitis and choroiditis;

· Sympathetic ophthalmia;

· Allergic conjunctivitis;

· Keratitis;

· Chorioretinitis;

· Optic neuritis;

· Iritis and iridocyclitis.

6. Respiratory diseases.

· Symptomatic sarcoidosis;

· Lefler's syndrome, which is not amenable to treatment by other methods;

· Beryllium;

· Fulminant or disseminated pulmonary tuberculosis (used in combination with appropriate anti-tuberculosis chemotherapy);

· Aspiration pneumonitis.

7. Hematological diseases.

· Idiopathic thrombocytopenic purpura in adults;

· Secondary thrombocytopenia in adults;

· Acquired (autoimmune) hemolytic anemia;

· Erythroblastopenia (erythrocyte anemia);

· Congenital (erythroid) hypoplastic anemia.

8. Cancer.

As palliative therapy for the following diseases:

· Leukemia and lymphoma in adults;

· Acute leukemia in children.

9. Edema syndrome.

For induction of diuresis or elimination of proteinuria in nephrotic syndrome without uremia, idiopathic type or caused by systemic lupus erythematosus.

10. Diseases of the digestive tract.

To remove the patient from a critical condition in the following diseases:

· Ulcerative colitis;

· Crohn's disease.

11. Diseases of the nervous system.

· Multiple sclerosis in the acute phase;

· Brain edema caused by a brain tumor.

12. Diseases of other organs and systems.

· Tuberculous meningitis with subarachnoid block or at the risk of block development, in combination with appropriate anti-tuberculosis chemotherapy;

· Trichinosis with damage to the nervous system or myocardium.

13. Organ transplantation.

Contraindication.

- Systemic fungal infections.

- Systemic infections in cases where specific antimicrobial therapy is not prescribed.

- Hypersensitivity to methylprednisolone or to the components of the drug listed in the section "Composition".

Administration of live or live attenuated vaccines is contraindicated in patients receiving immunosuppressive doses of corticosteroids.

Contraindications

- Systemic fungal infections.

- Systemic infections in cases where specific antimicrobial therapy is not prescribed.

- Hypersensitivity to methylprednisolone or to the components of the drug listed in the section "Composition".

Administration of live or live attenuated vaccines is contraindicated in patients receiving immunosuppressive doses of corticosteroids.

Dosage & Administration

The cruciform notch on the tablets is not functional and is not intended to separate the tablet.

The initial dose of the drug may vary depending on the indications. In less severe diseases, lower doses are usually sufficient, although some patients may require higher initial doses. High-dose therapy can be used in clinical situations such as cerebral edema (200–1000 mg / day), organ transplantation (up to 7 mg / kg / day), and multiple sclerosis. In the treatment of multiple sclerosis in the acute phase, oral administration of methylprednisolone 500 mg / day for 5 days or 1000 mg / day for 3 days is effective. If a satisfactory clinical effect is not achieved after a reasonable period of time, methylprednisolone tablet therapy should be discontinued and the patient should be given alternative therapy. If after long-term therapy the drug needs to be canceled, it is recommended to do it gradually, not suddenly.

Once a satisfactory effect has been achieved, the individual maintenance dose should be adjusted by gradually reducing the initial dose over time to the lowest dose that will maintain the clinical effect achieved. Keep in mind that you need to constantly monitor the dosage of the drug. Situations in which the dose of the drug may need to be adjusted include: changes in the clinical condition due to remission or exacerbation of the disease; individual patient response to the drug; the impact on the patient of stressful situations that are not directly related to the underlying disease to which the therapy is directed. In the latter case, it may be necessary to increase the dose of methylprednisolone for a certain period of time, depending on the patient's condition.

It should be emphasized that the required dose may vary and should be selected individually, depending on the nature of the disease and the patient's response to therapy.