Details
Norvasc Indications
Arterial hypertension; chronic stable angina / stenocardia; vasospastic angina (Prinzmetal angina).
Dosage & Administration
Adults. Usually, for the treatment of hypertension and angina pectoris the recommended initial dose of the drug Norvasc is amlodipine 5 mg 1 time per day. Depending on the patient's response to therapy dose can be increased to a maximum, which is 1 to 10 mg once a day.
Patients with angina. Norvasc may be used as monotherapy or in combination with other antianginal drugs in resistance to nitrates and / or adequate doses of β-adrenergic blockers.
There is experience with the drug in combination with thiazide diuretics, blockers, α-adrenergic, β-adrenergic receptors, or ACE inhibitors in patients with hypertension. No need for dose selection while the use of thiazide diuretics, β-adrenoceptor blockers and ACE inhibitors.
Children under the age of 6 years with hypertension. The recommended initial dose is Norvasc drug for these patients is 2.5 mg 1 time per day. If the desired level of blood pressure is not achieved during 4 weeks, the dose can be increased up to 5 mg / day. Use of the drug in doses> 5 mg has not been studied for this category of patients.
Elderly patients. No need for dose selection for this group of patients. Increasing the dose should be carried out with caution.
Patients with impaired renal function. It is recommended to use conventional doses because changes amlodipine plasma concentrations are not associated with the severity of renal insufficiency. Amlodipine is not displayed by dialysis.
Use for patients with hepatic failure. The doses of the drug for use in patients with hepatic insufficiency, mild to moderate is not installed, so the dose selection should be cautious and start with a low dose application (see. Cautions and Pharmacokinetics).
Tablets of 5 mg Norvasc drug are not intended to split in half for receiving a dose of 2.5 mg.
Contradictions
- Known hypersensitivity to dihydropyridines, amlodipine or to any other component of the drug;
- Hypotension, severe;
- Shock (including cardiogenic shock);
- Obstruction of the left ventricular tract outputting (eg aortic stenosis, severe);
- Haemodynamically unstable heart failure after acute myocardial infarction.
