Details
Lopril Indications
Essential hypertension, heart failure, post-myocardial infarction in patients with stable hemodynamics.
Dosage & Administration
Doses are assigned individually for each patient, depending on its state.
Essential and renovascular hypertension: The recommended initial dose - 2.5 mg / day; maintenance dose - 10-20 mg / day. The maximum dose - 40 mg / day. Dose does not increase by more than 10 mg to 2 week intervals.
Heart failure: the recommended initial dose - 2.5 mg / day maintenance dose - 5-10 mg / day. The maximum daily dose - 20 mg / day.
Acute myocardial infarction: patients with stable hemodynamic parameters within 24 hours after the onset of symptoms of acute myocardial infarction initial dose of 5 mg / day at 24 hours - 5 mg / day, after 48 hours - 10 mg / day. The maintenance dose for 6 weeks or more - 10 mg / day.
Patients with systolic blood pressure <120 mm Hg. Art. in the first 3 days after infarction administered 2.5 mg / day, followed by a maintenance dose of 5 mg / day. If the systolic blood pressure in the treatment decreased to 100 mm Hg. Art., the maintenance dose should be temporarily reduced from 5 to 2.5 mg / day. If hypotension is held after reducing the dosage, the drug should be discontinued. Lopril Bosnalek should not be administered to patients who have a systolic blood pressure <90 mm Hg. Art.
The dosage scheme in renal disease: Patients with creatinine clearance above 30 mL / min the usual starting dose is prescribed according to the statement. When creatinine clearance 30 to 10 mL / min, the initial dose - 2.5-5 mg / day (depending on indication). When creatinine clearance <10 ml / min and in patients on hemodialysis, the initial dose is 2.5 mg / day.
Contradictions
Hypersensitivity to the drug, angioneurotic edema (associated with the intake of ACE inhibitors in history), hereditary and idiopathic angioedema, aortic stenosis, renal artery stenosis, acute renal failure with a constantly high blood pressure during pregnancy and lactation, child age.
