Details
Accupro Indications
Arterial hypertension
Accupro indicated for the treatment of patients with hypertension. Quinapril is effective in monotherapy or in combination with thiazide diuretics and beta-blockers.
Congestive heart failure
Accupro is effective in the treatment of patients with chronic heart failure (in combination with diuretics and / or cardiac glycosides).
Dosage & Administration
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Monotherapy: The recommended initial dose Accupro for patients not taking diuretics, is 10-20 mg 1 time per day. Depending on the clinical response the dose can be increased to 20-40 mg / day. The recommended dose is used 1 time a day or divided into 2 doses. If necessary, dose adjustment may be carried out at intervals of 4 weeks. Continuous control is maintained in most patients with the dosing schedule 1 time per day. The maximum dose of quinapril is 80 mg / day.
Co-administration of diuretics in patients who must continue treatment with diuretics, the initial recommended dose is 5 mg Accupro and later it can be titrated to the optimal response (see INTERACTIONS.).
Congestive heart failure
Accupro used as an adjunct to therapy with diuretics and / or cardiac glycosides. The recommended initial dose in patients with congestive heart failure is 5 mg 1 or 2 times per day. If the initial dose is well tolerated in patients may be carried out to effectively titrate doses, typically from 10 to 40 mg / day, which was taken, divided into two equal doses.
Reduced kidney function: The kinetic data show that the elimination of quinapril depends on the level of renal function. Accupro is recommended starting dose for patients with a creatinine clearance of> 30 ml / min is 5 mg in patients with creatinine clearance <30 mL / min - 2.5 mg. If the initial dose is well tolerated, quinapril can be taken the next day at a dosage regimen 2 times per day. In the absence of excessive hypotension or significant deterioration of renal function the dose may be increased at weekly intervals based on clinical and hemodynamic response.
Contradictions
Hypersensitivity to any components of the drug; a history of angioneurotic edema associated with prior therapy with an ACE inhibitor; During pregnancy and breastfeeding; childhood. Cross-sensitivity to other ACE inhibitors has not been otsenena.lya treatment of patients with hypertension. Quinapril effective in monotherapy or in combination with thiazide diuretics and beta-blockers.
Congestive heart failure
Accupro is effective in the treatment of patients with chronic heart nedostatochnosyu (in combination with diuretics and / or cardiac glycosides).
