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VORICONAZOLE 200mg 10 tablets Вориконазол

VORICONAZOLE 200mg 10 tablets Вориконазол

Product sku: MD3358

Availability: In stock

Only 2 left

$299.99

Quick Overview

Antimicrobial agents for systemic use. Triazole derivatives. Voriconazole, Woriconazole, Voryconazole, Woryconazole
OR

Details

VORICONAZOLE INDICATIONS: 

Prevention of invasive fungal infections in allogeneic bone marrow transplantation in patients at high risk of such a complication.

Voriconazole is used for adults and children for the treatment of:

- invasive aspergillosis;

- candidaemia, which is not accompanied by neutropenia;

- severe invasive infections caused by Candida (including C. krusei) resistant to fluconazole;

- severe fungal infections caused by Scedosporium and Fusarium species.

Patients with advanced and potentially life-threatening infections should be treated with Voriconazole Vista as starting therapy.

APPLICATION

Voriconazole Vista should be taken at least 1 hour before or 1 hour after meals. Monitoring of electrolyte balance disorders, such as hypokalemia, hypomagnesemia, hypocalcemia, and, if necessary, their correction should be monitored before use and during use.

Treatment

Adults

Therapy should be started with a loading dose of Voriconazole-Vista to achieve a plasma concentration close to equilibrium on the first day. On the basis of high bioavailability with oral administration of the drug (96%) in case of clinical indication, the transition from intravenous to oral administration is made.

 

Contraindication:

 

- Hypersensitivity to the active substance or to any of the excipients.

- Coadministration with CYP3A4 substrates, terfenadine, astemizole, cisapride, pimozide or quinidine, as increased plasma concentrations of these drugs may lead to prolongation of QTs interval and occasionally to development of torsional (torsical) point (tades) (tades) (tades) (tades) section. "Interaction with other medicinal products and other types of interactions").

- Concomitant use with rifampicin, carbamazepine, and phenobarbital, as these drugs are able to significantly reduce voriconazole plasma concentrations (see section "Interactions with other medicinal products and other interactions").

- Concomitant use of standard doses of voriconazole with efavirenz at a dose of 400 mg per day or higher, since the use of efavirenz at such doses significantly reduces the plasma concentrations of voriconazole in healthy volunteers. Voriconazole also significantly increases the concentration of efavirenz in blood plasma (see section "Interactions with other medicinal products and other types of interactions"; for lower doses, see "Features").

- Concomitant use with high doses of ritonavir (400 mg or higher 2 times a day), since administration of such doses of ritonavir results in a significant decrease in the plasma concentration of voriconazole in healthy volunteers (see section “Application Features” for lower dose ritonavir).

- Concomitant use with horn alkaloids (ergotamine, dihydroergotamine), which are CYP3A4 substrates, as increased plasma concentrations of these drugs can lead to ergotism (see section "Interactions with other drugs and other interactions").

- Co-administration with sirolimus, as voriconazole can significantly increase the concentration of sirolimus in blood plasma (see section "Interaction with other medicinal products and other types of interaction").

- Simultaneous use with St. John's wort preparations (see section "Interaction with other medicinal products and other types of interactions").

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