Details
Colistin Alvogen Indications
Treatment of some severe infections caused by gram-negative bacteria, including lower respiratory tract and urinary tract infections, when more widely used systemic antibacterial agents are contraindicated or ineffective due to the development of bacterial resistance.
Contraindications
Hypersensitivity to colistimethate sodium (colistin) or to polymyxin B.
The patient has myasthenia gravis.
Dosage & Administration
The dose depends on the severity and type of infection, as well as the patient's age, weight and kidney function. If the clinical or bacteriological efficacy of the drug is slowed, the dose may be increased depending on the patient's condition.
Patients with impaired renal function, neonates and patients with cystic fibrosis are recommended to monitor the concentration of the drug in blood plasma. Concentrations of 10-15 mg / L (approximately 125-200 IU / ml) of sodium colistimethate should be sufficient to treat most infections. It is usually recommended to carry out treatment for at least 5 days.
