Accuzide 30 tablets 10mg Quinapril 12,5mg Hydrochlorotiaside Аккузид Arterial Hypertension treatment

Accuzide Indications

Treatment of hypertension in patients with appropriate use of combination therapy with quinapril and a diuretic.

Dosage & Administration

Patients who are not currently taking diuretics, regardless of whether they receive or not to quinapril monotherapy, Accuzide is recommended starting dose is 10 / 12.5 mg. In accordance with the clinical effect of the dose can be increased to 20 / 12.5 mg. Effective control of blood pressure in most cases is achieved through the use of a dose of 10 / 12.5 20 / 12.5 mg.

The range of dosage of the drug allows the flexibility to choose the ratio of the components, depending on clinical needs. Patients who have used a diuretic used to prevent excessive blood pressure lowering the recommended starting dose is 5 mg quinapril. Further dose chosen individually to achieve the desired effect. If the chosen ratio of quinapril and hydrochlorothiazide corresponds to that of the tablet, you can go to the reception Accuzide 10 or 20.

Dosage for patients with impaired renal function. Accuzide should not be used as the start of the drug in patients with impaired renal function (creatinine clearance <60 mL / min). In patients with moderate renal insufficiency (creatinine clearance 30-60 ml / min) therapy begins with the appointment of 5 mg quinapril with subsequent dose titration.
If necessary, additional diuretic their dose may be titrated using Accuzide. The starting dose is 10 / 12.5 mg. BP control is achieved by using Accuzide in normal doses.

If it becomes necessary to use in combination with diuretics quinapril in patients with severe renal (creatinine clearance <30 mL / min) should be preferred loop diuretics, thiazide instead. Consequently, patients with severe renal impairment is not recommended to use Accuzide drug.

Dosage for elderly patients. The therapeutic effect of the drug when used in the same doses was similar in patients older and mature, increasing the frequency of adverse events in elderly patients was observed.

Contradictions

Accuzide is contraindicated to patients with hypersensitivity to any component of the formulation; patients with a history of angioedema, the development of which has been associated with ACE inhibitors; during pregnancy and lactation; women planning pregnancy and women of childbearing age who do not use reliable contraception.

As part of the preparation includes hydrochlorothiazide, Accuzide 10 and 20 is contraindicated in patients with anuria or hypersensitivity to quinapril, thiazides and any derivative of sulfonamide drugs.

The drug is contraindicated to patients with aortic stenosis and obstruction of the outflow tract; patients with congenital / idiopathic angioedema.