Details
Lincomycin Indications
Treatment of infections caused by susceptible strains of gram-positive aerobic or anaerobic bacteria:
- ENT organs, including tonsillitis, pharyngitis, otitis media, sinusitis, mastoiditis; scarlet fever, and as an auxiliary therapy for diphtheria;
- Respiratory tract, including acute and chronic bronchitis, pneumonia;
- Skin and soft tissues, including panniculitis, abrasions, abscesses, impetigo, acne, wound infections; as well as diseases such as erysipelas, lymphadenitis, paronychia (felon), mastitis and gangrene of the skin;
- Bones and joints, including osteomyelitis and septic arthritis;
- Septicemia and endocarditis;
- Bacterial dysentery. Although Shigella is resistant to lincomycin in vitro (minimum inhibitory concentration about - 200-400 mg / ml), lincomycin is effective for the treatment of dysentery, as in the intestine achieved very high levels of lincomycin (about 3000-7000 mg / g of faeces).
Contraindications
Hypersensitivity to the drug or to clindamycin in history. Pregnancy (except when necessary for health reasons). Severe liver and / or kidney failure. The period of lactation. Children age 1 month. Serious fungal diseases of the skin, mucous membrane of the mouth, vagina. Myasthenia. Colitis, diarrhea unexplained origin.
Dosage & Administration
Before using the drug to carry out skin test for sensitivity to Lincomycin-Darnitsa.
Adults
A. Intramuscular injection.
The usual dose is:
1. 600 mg intramuscularly every 24 hours.
2. More severe infections: 600 mg intramuscularly every 12 hours (or more), determined the severity of the infection.
B. Intravenous injection.
The usual dose is:
1. From 600 mg to 1 g every 8-12 hours.
2. In more serious infections, these doses can be increased.
3. In conditions that pose a threat to life, the daily dose for intravenous administration may take up to 8 hours
Children (over 1 month).
A. Intramuscular injection.
1) 10 mg / kg / day in a 1 intramuscular injection.
2) More severe infections - 10 mg / kg every 12 hours or more.
B. Intravenous injection.