Details
Fareston Indications
Treatment of hormone-dependent metastatic breast cancer in postmenopausal women as a first-line drug.
Fareston is not recommended for patients with estrogen receptor-negative tumors.
Contradictions
History of endometrial hyperplasia and severe hepatic insufficiency are contraindications to long-term use of toremifene.
Hypersensitivity to toremifene or to any of the excipients.
With the use of toremifene there were changes in cardiac conductivity, namely - prolongation of the QT interval, so the drug is contraindicated in patients with:
- congenital or acquired prolongation of the QT interval;
- electrolyte imbalance, especially with uncorrected hypokalemia;
- clinically significant bradycardia;
- clinically significant heart failure with decreased left ventricular ejection fraction;
- history of symptomatic arrhythmias.
Toremifene is not recommended for use with drugs that prolong the QT interval.
Dosage & Administration
The drug is intended for oral use regardless of food intake.
The recommended dose is 60 mg per day.
Renal failure.
No dose adjustment is required in renal insufficiency.
Hepatic failure.
In hepatic insufficiency, toremifene should be used with caution.