Details
Allopurinol Indications
Adults:
- Hyperuricemia (the level of uric acid in the serum of 500 mmol / L (8.5 mg / 100 ml) or higher, which is not controlled by diet)
- Diseases caused by increased levels of uric acid in the blood, especially gout, urate nephropathy and urate kidney stones
- Secondary hyperuricemia various etiologies, including psoriasis
- Primary and secondary hyperuricemia in various hemoblastoses (acute leukemia, chronic myelogenous leukemia, lymphosarcoma)
- Cytotoxic therapy neoplastic and myeloproliferative diseases.
Children:
- Urate nephropathy as a result of treatment of leukemia;
- Secondary hyperuricemia different etiology;
- Congenital enzyme deficiency, including syndrome Lesch-Niyena (partial or complete deficiency of hypoxanthine-guanine) and congenital deficiency of adenine.
Contraindications
- Hypersensitivity to allopurinol or other components of the drug
- Severe hepatic impairment or renal (creatinine clearance less than 2 ml / min)
- Acute attack of gout
- Galactose intolerance, lactase deficiency, glucose-galactose syndrome malabsorption
Dosage & Administration
Take after food without chewing, drinking plenty of water.
Adults and children aged 10 years to determine the daily dose individually depending on the level of uric acid in the blood serum. Typically, the daily dose is 100-300 mg / day. To reduce the risk of adverse reactions should start treatment with receiving allopurinol 100 mg once daily.
