Details
ACYCLOVIR 800 STADA indications
- Treatment of viral infections of the skin and mucous membranes caused by the herpes simplex virus, including primary and recurrent genital herpes.
- Suppression (prevention of recurrence) of infections caused by the herpes simplex virus in patients with normal immunity.
- Prevention of infections caused by herpes simplex virus in patients with immunodeficiency.
- Treatment of infections caused by Varicella zoster virus (chickenpox and shingles).
Contraindications
Hypersensitivity to acyclovir, valacyclovir or to any other components of the drug.
Dosage & Administration
The tablet should be taken whole with water. When using high doses of acyclovir, it is necessary to maintain an adequate level of hydration.
Adults
Treatment of infections caused by the herpes simplex virus
For the treatment of infections caused by the herpes simplex virus, take acyclovir 200 mg tablets 5 times a day at approximately 4-hour intervals, except at night.
Treatment should last 5 days, but in case of severe primary infection it can be continued.
For patients with severe immunodeficiency (eg after bone marrow transplantation) or for patients with reduced intestinal absorption, the dose may be doubled to 400 mg or the appropriate dose for intravenous administration.
Treatment should be started as early as possible after the onset of infection. In case of recurrent herpes, it is best to start treatment in the prodromal period or after the first signs of skin lesions.
Prevention of recurrence (suppressive therapy) of infections caused by herpes simplex virus
In patients with normal immunity to prevent recurrence of infections caused by the herpes simplex virus, tablets at a dose of 200 mg should be taken 4 times a day with an interval of 6 hours.
For convenience, most patients can take 400 mg of acyclovir twice daily at 12-hour intervals.
Treatment will be effective even after reducing the dose of acyclovir to 200 mg, which should be taken 3 times a day with an 8-hour interval or even 2 times a day with a 12-hour interval.
In some patients, radical improvement is observed after taking a daily dose of acyclovir 800 mg.
To monitor possible changes in the natural course of the disease, acyclovir therapy should be interrupted periodically at intervals of 6-12 months.
Prevention of infections caused by the herpes simplex virus
To prevent infections caused by the herpes simplex virus, patients with immunodeficiency should take the 200 mg tablet 4 times a day at 6-hour intervals. For patients with severe immunodeficiency (eg, after bone marrow transplantation) or for patients with reduced intestinal absorption, the dose may be doubled to 400 mg or the appropriate dose for intravenous administration.
The duration of prevention depends on the length of the risk period.
Treatment of chickenpox and shingles
For the treatment of infections caused by chickenpox and shingles, tablets should be taken at a dose of 800 mg 5 times a day at 4-hour intervals, except at night. The treatment should last 7 days.
In patients with severe immunodeficiency (eg, after bone marrow transplantation) or in patients with reduced intestinal absorption, it is better to use intravenous administration.
Treatment should be started as early as possible after the onset of the disease, the result will be better if treatment is started immediately after the appearance of the rash.
Children
For the treatment and prevention of infections caused by the herpes simplex virus, children with immunodeficiency from the age of 2 years can use doses as for adults.
For the treatment of chickenpox in children aged 6 years, prescribe 800 mg of acyclovir 4 times a day, children aged 2 to 6 years can receive 400 mg of acyclovir 4 times a day. The duration of treatment is 5 days.
The exact dose of the drug can be calculated by the child's body weight: 20 mg / kg body weight per day (not to exceed 800 mg) of acyclovir in 4 doses.
This dosage form should not be used in children under 2 years of age.
Elderly patients
It should be borne in mind the possibility of renal dysfunction in elderly patients, the dose of the drug for them should be changed accordingly (see "Renal failure"). It is necessary to maintain an adequate level of hydration of the body.
Renal failure
Acyclovir should be used with caution in patients with renal insufficiency. It is necessary to maintain an adequate level of hydration of the body.
In the prevention and treatment of infections caused by the herpes simplex virus, oral doses are recommended for patients with renal insufficiency that do not result in the accumulation of acyclovir, which would exceed the safe level established for intravenous administration. However, for patients with severe renal insufficiency (creatinine clearance less than 10 ml / min), it is recommended to set the dose to 200 mg twice daily with an interval of approximately 12 hours.
In the treatment of infections caused by Varicella zoster virus (chickenpox and shingles), for patients with significantly reduced immunity, it is recommended that in patients with severe renal insufficiency (creatinine clearance less than 10 ml / min) a dose of 800 mg twice daily with an interval of approximately 12 hours , and for patients with moderate renal insufficiency (creatinine clearance in the range of 10-25 ml / min) - 800 mg 3 times a day with an interval of approximately 8 hours.
If it is necessary to prescribe a drug in a dose less than 400 mg, use acyclovir in the appropriate dosage or dosage form.
